Thermo Fisher Scientific PrP Recombinant Rabbit Monoclonal Antibody (ARC1315)
Recombinant rabbit monoclonal antibody (clone ARC1315) specific to PrP. Validated for WB and ELISA in human, mouse, and rat samples. Supplied as liquid at 0.4 mg/mL in PBS with glycerol. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1315 |
| Immunogen | Synthetic peptide corresponding to amino acids 154–253 of human Prion Protein (P04156) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849624 |
Product Specific Information
Immunogen sequence:
MHRYPNQVYY RPMDEYSNQN NFVHDCVNIT IKQHTVTTTT KGENFTETDV KMMERVVEQM CITQYERESQ AYYQRGSSMV LFSSPPVILL ISFLIFLIVG
Target Information
Human prion protein (PrP), also known as PRNP, is a GPI-anchored cell surface glycoprotein associated with lipid raft components and functions as a signaling molecule. PrP plays a role in apoptosis, epithelial cell proliferation, and distribution of junction-associated proteins. Conversion of the normal cellular form (PrPc) into the abnormal conformer (PrPSc) is a key event in prion neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD). PrPc is rich in α-helices, while PrPSc has higher β-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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