Thermo Fisher Scientific TDP-43 Recombinant Superclonal Antibody (1HCLC)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Bovine, and Horse.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of a mixture of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

Unlike traditional polyclonal antibodies that vary between lots, recombinant Superclonal™ antibodies maintain identical composition across batches, ensuring reproducible results.

Note: Formerly called “Recombinant Polyclonal Antibody”, this product is now rebranded as “Recombinant Superclonal™ Antibody”. The physical product and performance remain unchanged.

Target Information

TDP43 was first identified as a cellular protein binding to the HIV-1 TAR DNA sequence and acting as a transcriptional repressor. It also regulates splicing of exon 9 of the CFTR gene, likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 (pathologic TDP43) is a major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U).
TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.