Thermo Fisher Scientific CD45/LCA Polyclonal Antibody
Rabbit polyclonal antibody targeting human CD45/LCA. Validated for WB and IHC-P applications. Purified by antigen affinity chromatography. Supplied as liquid in PBS with stabilizer and 0.01% sodium azide. Suitable for research use only.
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- 500-10564
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encoding aa 1119–1304 of human CD45 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Tonsil
- Cellular location: Cell membrane
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of lymphocyte surface proteins. It is absent in non-hematopoietic cells and tissues.
CD45 plays a key role in lymphocyte development and antigen signaling by regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions.
CD45RA is one such isoform with cell type–specific expression. CD45 modulates T- and B-cell receptor signaling, suppresses JAK kinases, and influences cytokine receptor signaling, integrin-mediated pathways, and apoptosis-related processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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