Thermo Fisher Scientific CD14 Polyclonal Antibody
CD14 단백질을 인식하는 Rabbit Polyclonal 항체로 인간 시료에 반응합니다. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 안정화제가 포함된 PBS에 보관됩니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- 500-10554
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encoding aa 1–201 of human CD14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Jurkat cells, Placenta
- Cellular location: Cytoplasmic, membrane
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils.
It functions as a multifunctional lipopolysaccharide receptor and is released to serum both as a secreted and enzymatically cleaved form.
CD14 binds lipopolysaccharide molecules catalyzed by LBP (lipopolysaccharide-binding protein), an acute-phase serum protein.
Soluble sCD14 can discriminate structural differences between lipopolysaccharides and aids in neutralization of serum lipopolysaccharides.
CD14 also binds apoptotic cells and influences allergic, inflammatory, and infectious processes.
Alternative splicing results in multiple transcript variants encoding the same CD14 isoform.
Diseases associated with CD14 dysfunction include Mycobacterium chelonae infection and Croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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