Thermo Fisher Scientific AKAP3 Polyclonal Antibody

Thermo Fisher Scientific AKAP3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE KSTAEFQDVR FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE MTHKEIPCQG PRAQLGNGSS VDEVSFYANR LTNLVIAMAR KEINEKIDGS ENKCVYQSLY MGNEPTPTKS LSKIASELVN ETVSACSRNA APDKAPGSGD RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF FYKEVFESRN GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI

Target Information

The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by compartmentalization of the kinase within the cell. The R subunit (RII) of PKA interacts with A-kinase anchoring proteins (AKAPs).
AKAP3 (also known as AKAP110, FSP95, PRKA3, SOB1) binds PKA and PDE4A, functioning as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions.
Expression of AKAP3 is restricted to testis tissue, where bicarbonate stimulates tyrosine phosphorylation of AKAP3, increasing its recruitment of PKA. AKAP3 also shows high expression in epithelial ovarian cancer (EOC) and may serve as a potential target for antigen-specific immunotherapy.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.