Thermo Fisher Scientific TRPM8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide: R(278) N Q L E K Y I S E R T I Q D(292) and synthetic peptide to the C terminus: (1090) N D L K G L L K E I A N K I K(1104). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRPM8,uniProtId:Q7Z2W7-1,ncbiNodeId:9606,antigenRange:278-292,antigenLength:1104,antigenImageFileName:PA1-4282_TRPM8_Q7Z2W7-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4282_TRPM8_Q7Z2W7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_561854

Product Specific Information

PA1-4282 detects the Trp-p8 protein in human samples.

PA1-4282 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~125 kDa protein representing Trp-p8 in transfected COS cells.

PA1-4282 immunizing peptide corresponds to amino acid residues 278-292 and the C terminus sequence of the human Trp-p8 protein.

Target Information

TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.