Thermo Fisher Scientific Tocilizumab Recombinant Human Monoclonal Antibody (rhPM-1 (Tocilizumab))
Tocilizumab 인간 단일클론 항체로 IL-6 수용체에 특이적으로 결합하여 염증 반응을 억제합니다. HEK293 세포에서 발현된 재조합 항체로 ELISA 및 억제 분석에 사용됩니다. Protein A로 정제되었으며 PBS와 ProClin 300을 포함한 액상 형태로 제공됩니다.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rhPM-1 (Tocilizumab) |
| Immunogen | The original antibody was generated by CDR grafting of mouse PM-1 antibody onto human REI and NEW framework regions to create rhPM-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074504 |
Product Specific Information
Tocilizumab binds specifically to both the membrane-bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
Target Information
Tocilizumab (Actemra) is a humanized monoclonal antibody developed by Hoffmann-La Roche and Chugai for the treatment of patients with rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis. It binds to the interleukin-6 receptor (IL-6R) and blocks its interaction with interleukin 6 (IL-6), hindering IL-6 from exerting its pro-inflammatory effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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