Thermo Fisher Scientific INSR alpha Chimeric Recombinant Rabbit Monoclonal Antibody (Fab 83-7)
인슐린 수용체 알파 서브유닛을 인식하는 재조합 토끼 단일클론 항체입니다. 인간 시료에 반응하며 ICC/IF 및 in vitro assay에 사용 가능합니다. HEK293 세포에서 발현되었으며 Protein A로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| In vitro Assay (IV) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Fab 83-7 |
| Immunogen | This antibody was raised by immunizing mice with IM-9 lymphocytes followed by purified insulin receptor. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074501 |
Product Specific Information
Specificity: This antibody recognizes an epitope within the cysteine-rich region (amino acids 140–301) of the extracellular domain of the human insulin receptor alpha.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence in regions that confer ligand specificity and in certain intracellular signaling domains, resulting in functional differences. Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are also important in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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