Thermo Fisher Scientific NeuN Polyclonal Antibody
NeuN(Fox-3) 단백질을 인식하는 산양 유래 polyclonal antibody로, 인간, 생쥐, 랫트 시료에 반응합니다. Western blot, IHC(P), IHC(PFA), ICC/IF 등 다양한 응용에 적합하며, 고순도의 affinity chromatography 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000–1:5,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | N-terminal 100 amino acids of human Fox3 expressed in and purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 5 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2942815 |
Target Information
Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17: p53 and BRCA1.
- p53: Maintains genetic integrity by balancing DNA repair and cell death; its malfunction or loss is linked to malignant cell growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and recognized as a genetic determinant of early-onset breast and ovarian cancers, as well as cancers of the colon, prostate, and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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