Thermo Fisher Scientific Nestin Polyclonal Antibody
Nestin 단백질을 인식하는 Chicken IgY 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. WB, IHC, ICC/IF 등 다양한 응용에 적합하며, 신경줄기세포 및 종양 내 혈관신생 연구에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant construct, amino acids 317–630 of the human Nestin protein expressed and purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2942807 |
Target Information
Nestin is a Class VI intermediate filament abundantly produced in the developing central nervous system (CNS) and in early embryonic neuroepithelial stem cells. It serves as a predominant marker for stem/progenitor cells, glioma cells, and tumor endothelial cells. Nestin is also recognized as a superior angiogenic marker for evaluating neovascularity in tumors.
Highly specific antibodies to human Nestin can assist in:
- Characterizing progenitor cells differentiating into distinct lineages
- Enhancing therapeutic potential of human neural stem/progenitor cells in CNS disease or injury
- Identifying neuroepithelial tumor cells
Nestin expression has been observed in pancreatic hematopoietic stem cell populations and is considered a novel angiogenesis marker in proliferating endothelial cells within colorectal cancer tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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