Thermo Fisher Scientific CACNA1S Monoclonal Antibody (2C5)
CACNA1S 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 2C5). 인간 시료 반응성, ELISA 검증, 고순도 친화 크로마토그래피 정제. 연구용으로 사용되며, 전압 민감성 칼슘 채널 연구에 적합.
- 카탈로그번호
- H00000779-M01
- 판매단위
- pk
카탈로그
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Applications
- ELISA (ELISA)
Tested Dilution
- 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C5 |
| Immunogen | CACNA1S (NP_000060, 1743–1838 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CPRVESSMPE DRKSSTPGSL HEETPHSRST RENTSRCSAP ATALLIQKAL VRGGLGTLAA DANFIMATGQ ALGDACQMEP EEVEIMATEL LKGREA
Target Information
Voltage-sensitive calcium channels mediate calcium entry into excitable cells, playing a key role in neurotransmitter release and excitation-contraction (E-C) coupling.
1,4-dihydropyridines (DHPs) are synthetic compounds used to identify L-type calcium channels found in muscle, neuronal, and neuroendocrine cells.
The DHP receptor, part of the L-type calcium channel complex, acts as the voltage sensor in E-C coupling and consists of at least four subunits:
- Alpha-1 subunit: contains the DHP binding site, homologous to voltage-gated sodium channels
- Alpha-2 subunit: large glycoprotein found in skeletal and cardiac muscle, brain, and other excitable tissues
- Beta and Gamma subunits: co-purify with the DHP receptor
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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