Thermo Fisher Scientific TNNI3 Monoclonal Antibody (OTI3B4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cardiac Troponin I (TnI) is a cardiac-specific inhibitory protein that forms a complex with troponin C (TnC) and troponin T (TnT).
It plays a crucial role in muscle contraction by regulating the interaction between actin and myosin through calcium-mediated conformational changes.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of cardiac muscle damage, useful for differentiating between angina and myocardial infarction.
Mutations in the TNNI3 gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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