Thermo Fisher Scientific CNOT4 Monoclonal Antibody (OTI1G3), TrueMAB
CNOT4 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 적합. Human 반응성, 비결합형 형태이며 동결건조 상태로 제공. 단백질 유비퀴틴화 연구 및 전사 조절 복합체 분석에 활용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 190–455 of human CNOT4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, involved in protein modification and ubiquitination. It contains:
- A C4C4-type RING zinc finger domain
- An RNA recognition motif
- A bipartite nuclear localization signal
CNOT4 is part of the CCR4-NOT (CAF1) core complex, regulating transcription of various genes. It interacts with CNOT1 via its C-terminus and with E2 ubiquitin ligases via the C4C4 RING domain. Reports indicate that CNOT4 is phosphorylated in response to DNA damage at consensus sites recognized by ATM and ATR.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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