Thermo Fisher Scientific CD44var (v10) Monoclonal Antibody (VFF-14), eBioscience

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (IHC)

• Tested
• View 1 publication

Flow Cytometry (Flow)

• Tested
• View 1 publication

Product Specifications

Product Specific Information

Specifically recognizes an epitope encoded by exon v10 on the variant portion of human CD44.
Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin.
The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain.
These isoforms include CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.

• Applications Tested: Western Blot
• Purity: >95%

Target Information

CD44 cell surface antigen is a 100 kDa glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast.
Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
It participates in lymphocyte activation, recirculation, and homing.
CD44 expression may be up-regulated in certain carcinomas and may be related to metastatic potential.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.