Thermo Fisher Scientific ErbB2 (HER-2) Monoclonal Antibody (2G11), Biotin, eBioscience
HER-2 단백질을 표적하는 Biotin 결합 단클론 항체로, 인간 시료에 반응하며 Flow Cytometry, WB, ICC/IF, IP에 활용 가능. HER-2 과발현 암 연구에 적합하며, 고순도(>95%)로 제조됨. 2-8°C 보관, 연구용 전용.
- 카탈로그번호
- BMS120BT
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Flow Cytometry (Flow) | Assay-Dependent | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G11 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 10 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.2–7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10598667 |
| Purity | >95% |
Available Formats
Product Specific Information
The antibody (clone 2G11) can be used to stain cryostat sections or cell smears.
BMS120 is suitable as a primary antibody for FACS analysis.
BMS120FI can be used for direct staining of cells, while BMS120BT can be applied in a two-step procedure using the biotin-(strept)avidin system.
The epitope is located in the extracellular domain, and no cross-reactivity with EGF-R has been detected by immunoprecipitation.
HER-2 oncogene amplification and oncoprotein overexpression have been correlated with breast, ovarian, gastric, lung, and other cancers.
In 15–40% of primary breast cancers, HER-2 amplification is found and is highly correlated with overexpression of the encoded protein, playing a major role in the initiation of ductal carcinomas. HER-2 overexpression serves as an independent prognostic factor with greater predictive power than most current prognostic tools, especially in axillary lymph-node-positive breast cancer patients.
Approximately 32% of ovarian carcinomas overexpress the HER-2 oncoprotein, and survival of these patients is significantly worse compared with cases of normal HER-2 expression. Patients with high HER-2 expression also show lower complete response rates to primary therapy.
A correlation between HER-2 expression and clinical outcome has been demonstrated for head and neck, salivary gland, and placental carcinomas.
HER-2 is useful in identifying cancer cells with increased aggressiveness.
Soluble p97-115 HER-2 (the circulating fragment of p185 HER-2) levels in serum can be used as a diagnostic tool for monitoring tumor spread, postoperative relapse, and metastatic risk in various cancers.
Applications Tested: Flow Cytometry.
Target Information
ErbB2 (HER2) is a receptor tyrosine kinase overexpressed in certain breast tumors.
Herceptin, a monoclonal antibody targeting this kinase, is used in the treatment of metastatic HER2-positive cancers.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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