Thermo Fisher Scientific MPP10 Polyclonal Antibody
Thermo Fisher Scientific의 MPP10 폴리클로날 항체로, 인간, 마우스, 랫트 시료에서 MPP10 단백질 검출에 사용됩니다. Western blot에 최적화되어 있으며, 고순도(>95%) 항체입니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 126–171 of human MPP10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553847 |
Product Specific Information
- Detects endogenous MPP10 protein at molecular weights of 79 kDa and 120 kDa (phosphorylated form).
- Purity: >95% by SDS-PAGE.
Target Information
MPP10 (M-phase phosphoprotein 10), also known as MPHOSPH10, is a 681 amino acid protein localized in the fibrillar region of the nucleolus. It is phosphorylated during the mitotic (M) phase of the cell cycle and functions as a component of the 60–80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex, essential for early cleavages during pre-18S rRNA processing.
MPP10 forms a heterotrimeric complex with IMP-3 and IMP-4, facilitating its association with nucleolar components. The MPP10 gene is located on human chromosome 2, which contains over 500 genes. Mutations in genes on chromosome 22 are associated with Phelan-McDermid syndrome, Neurofibromatosis type 2, autism, and schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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