Thermo Fisher Scientific Human TGF-alpha Recombinant Protein
인간 TGF-alpha 재조합 단백질로, EGF 수용체를 통해 다양한 상피세포 증식을 유도합니다. E. coli 발현 시스템에서 생산되었으며, SDS-PAGE 기준 98% 이상 순도와 낮은 엔도톡신 수준을 가집니다. 기능적 활성 검증 완료, 연구용으로 적합합니다.
- 카테고리
- Protein
- 판매단위
- pk
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Thermo Fisher Scientific Human TGF-alpha Recombinant Protein
Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- ELISA: Assay-dependent
- Functional Assay: Assay-dependent
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA |
| Molecular Weight | 5.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >98% by SDS-PAGE |
| Endotoxin Concentration | <0.1 ng/µg |
| Activity | ED50 ≤ 0.2 ng/mL; determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
Product Specific Information
Carrier-Free
Reconstitution:
Briefly centrifuge vial before opening to collect contents at the bottom. Reconstitute in water to a concentration of 0.1–1.0 mg/mL. Do not vortex. Store at 2°C–8°C for up to 1 week. For extended storage, dilute in buffer containing 0.1% BSA and store aliquots at -20°C to -80°C.
Storage:
Lyophilized protein is stable at room temperature for 1 month; store at -20°C for long-term storage. Working aliquots with carrier protein are stable for ≥3 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles.
Target Information
TGF-alpha is an EGF-related growth factor that signals through the EGF receptor and stimulates proliferation of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and tumor cells, and induces anchorage-independent transformation in cultured cells. Human, murine, and rat TGF-alpha are cross-species reactive. TGF-alpha binds EGFR, activates receptor tyrosine phosphorylation, and promotes cell proliferation. It plays a role in tumor initiation by inducing a reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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