Thermo Fisher Scientific DCLK1 Polyclonal Antibody
Thermo Fisher Scientific의 DCLK1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB 및 IHC 실험에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 인간 뇌 조직 라이세이트를 양성 대조군으로 사용할 수 있습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | - |
| Immunohistochemistry (IHC) | 2.5 µg/mL | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid synthetic peptide near the amino terminus of human DCLK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154526 |
Product Specific Information
- Suggested positive control: human brain tissue lysate
- PA5-20908 can be used with blocking peptide PEP-1022
- The immunogen is located within the last 50 amino acids of DCLK1
Target Information
DCAMKL1 (DCLK1), also known as doublecortin-like kinase 1, is a serine/threonine kinase containing two N-terminal doublecortin domains that bind microtubules and regulate microtubule polymerization.
It also includes a C-terminal serine/threonine protein kinase domain homologous to Ca²⁺/calmodulin-dependent protein kinase, and a serine/proline-rich domain between these regions that mediates multiple protein-protein interactions.
DCLK1 can undergo autophosphorylation and exhibits microtubule-polymerizing activity independent of its kinase activity.
It is involved in neuronal migration, retrograde transport, neuronal apoptosis, and neurogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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