Thermo Fisher Scientific Phospho-MUC1 (Ser1227) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of CD227/MUC1 only when phosphorylated at Ser1227.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through proteolysis and extensive glycosylation, resulting in heavy sialylation.
MUC1 is highly polymorphic, with allelic variants containing 30–90 tandem repeats, leading to variable molecular weights. It is abundantly expressed in >90% of breast carcinomas and metastases.
Transgenic MUC1 has been shown to associate with all four CebB receptors and localize with ErbB1 (EGFR) in lactating glands. Overexpression, aberrant intracellular localization, and altered glycosylation are associated with carcinomas. Multiple alternatively spliced transcript variants exist, encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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