Thermo Fisher Scientific MRC2 Polyclonal Antibody
MRC2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human MRC2 (UniProt ID: Q9UBG0-1, amino acids 139–158) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635339 |
Product Specific Information
This antibody detects endogenous levels of total MRC2 protein.
Target Information
MRC2 may function as an endocytic lectin receptor with calcium-dependent activity, internalizing glycosylated ligands via clathrin-mediated endocytosis. It may play a role in the plasminogen activation system, regulating PLAUR/PLAU and protease activity at the cell surface. MRC2 contributes to the uptake, remodeling, and degradation of extracellular collagen matrices, potentially influencing cancer progression and chronic tissue-destructive diseases through collagen turnover. It may also cooperate with matrix metalloproteinases (MMPs) in extracellular matrix remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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