Thermo Fisher Scientific Ubiquitin B Polyclonal Antibody

Applications and Tested Dilution

• Application: Immunocytochemistry (ICC/IF)
• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (99%), Xenopus laevis (99%), Pig (100%), Chicken (100%), Sheep (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%).
• Positive Control: Target recombinant protein.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which plays an ATP-dependent role in targeting proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C-terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes.

Ubiquitin also becomes covalently bonded to many types of pathological inclusions that are resistant to normal degradation. Therefore, ubiquitin antibodies are valuable tools for studying these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer’s disease, Lewy bodies in Parkinson’s disease, and Pick bodies in Pick’s disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.