Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Arginase 1 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ELISA 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로, Arginase-1 단백질 연구 및 대사 관련 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | 3 publications |
| Immunohistochemistry (IHC) | – | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
| Flow Cytometry (Flow) | 1:50–1:200 | 1 publication |
| ELISA | 1:1,000–1:10,000 | – |
| Immunoprecipitation (IP) | 1:100–1:1,000 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human Arginase 1 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792410 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (86%), Rat (86%), Pig (89%), Rabbit (91%), Bovine (90%)
- Positive Control: Huh7, HepG2, mouse liver, rat liver
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 reduces nitric oxide production by limiting substrate availability for NO synthase.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells. In humans, it is expressed in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 is often expressed in tumor-infiltrating myeloid cells and is commonly found in hepatocellular carcinoma. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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