Thermo Fisher Scientific SFRP4 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 SFRP4 폴리클로날 항체로 Western Blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. Wnt 신호 억제 연구 및 암, 당뇨, 피부 질환 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human SFRP4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720662 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is > 95% (by SDS-PAGE).
Target Information
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain homologous to Frizzled proteins. sFRPs lack transmembrane and intracellular domains, functioning as soluble modulators of the Wnt signaling pathway by directly binding Wnt proteins and inhibiting receptor interaction.
sFRP-4 is expressed in various embryonic and adult tissues and acts as an antiangiogenic and proapoptotic factor, inhibiting insulin secretion and tumor growth through Wnt pathway suppression. Reduced circulating sFRP-4 correlates with cancer progression (ovarian, endometrial, prostate, lung), while increased levels are linked to type 2 diabetes and reduced keratinocyte hyperproliferation in psoriasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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