Thermo Fisher Scientific VAMP A/B Polyclonal Antibody
Rabbit polyclonal antibody recognizing VAMP A and B proteins. Suitable for WB and IHC in human, mouse, and rat samples. Lyophilized form, reconstitutable in sterile water. For research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 50–100 of human VAMPB conjugated to an immunogenic carrier protein. Target family: VAPA/VAPB (UniProt ID: O95292-1, NCBI Node ID: 9606). Antigen range: 50–100. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in many species including human, rat, mouse, zebrafish, bovine, xenopus, and chicken.
- Specificity: VAMP A and B.
Target Information
VAPA/VAPB may play a role in vesicle trafficking. Present in the plasma membrane and intracellular vesicles. Interacts with VAMP1 and VAMP2.
Subunit: Homodimer and heterodimer with VAPA.
Subcellular Location: Cell membrane; Single-pass type IV membrane protein. Intracytoplasmic membrane; Single-pass type IV membrane protein.
Tissue Specificity: Ubiquitous. Isoform 1 predominates.
Disease Associations:
- Defects in VAPB cause amyotrophic lateral sclerosis type 8 (ALS8), a familial neurodegenerative disorder affecting motor neurons.
- Also associated with proximal adult autosomal dominant spinal muscular atrophy (late-onset Finkel type).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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