Thermo Fisher Scientific CD47/IAP (Integrin Associated Protein) Monoclonal Antibody (CD47/2937), Biotin
인간 CD47 단백질을 표적으로 하는 단클론성 항체로, Biotin 접합 형태. Western blot, IHC, ELISA 등 다양한 응용에 적합. 고순도 Protein A/G 정제 및 안정적 PBS 버퍼 저장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD47/IAP (Integrin Associated Protein) Monoclonal Antibody (CD47/2937), Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD47/2937 |
| Immunogen | Recombinant fragment (around aa 18–135) of human CD47 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein that interacts with several integrins and regulates their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, including activation of heterotrimeric G proteins. Functionally, CD47 is involved in increasing intracellular calcium concentration upon cell adhesion to extracellular matrix.
CD47 also serves as a receptor for the C-terminal cell binding domain of thrombospondin and may play roles in membrane transport and signal transduction. It has broad tissue distribution and reduced expression on Rh erythrocytes. CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRPα), an immune inhibitory receptor on macrophages, preventing phagocytosis of CD47-positive cells. The CD47–CD172a system influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanical response modulation, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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