Thermo Fisher Scientific CD47/IAP (Integrin Associated Protein) Monoclonal Antibody (IAP/964, B6H12.2)
CD47/IAP 단백질을 인식하는 마우스 모노클로날 항체로 인간 시료에 반응합니다. Western blot, ICC/IF, Flow cytometry, 기능 분석 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IAP/964, B6H12.2 |
| Immunogen | Recombinant human IAP protein (IAP/964); Intact CD47 purified from placenta (B6H12.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein that interacts with several integrins and regulates their functions. Engagement of CD47 by soluble ligands or counter receptors modulates signaling pathways such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in increasing intracellular calcium concentration upon cell adhesion to the extracellular matrix.
CD47 also serves as a receptor for the C-terminal cell-binding domain of thrombospondin and may play roles in membrane transport and signal transduction. It has broad tissue distribution but reduced expression on Rh erythrocytes.
CD47 acts as a ligand for CD172a (SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Additionally, the CD47–CD172a system influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanotransduction, and neuronal development, being abundant in synapse-rich regions of the brain and retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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