Thermo Fisher Scientific CD47/IAP (Integrin Associated Protein) Monoclonal Antibody (CD47, 2937)
CD47/IAP 단백질을 인식하는 Mouse Monoclonal Antibody로, Human 시료에 반응. Western Blot, IHC, Peptide Array 등에 사용 가능. PBS 기반 액상 형태로 보존제 없음. 단백질 A/G로 정제되어 -20°C 이하에서 안정적으로 보관.
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- 961-MSM7-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD47, 2937 |
| Immunogen | Recombinant fragment (aa 18–135) of human CD47 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Tested in direct ELISA.
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cooling for 20 min at RT. - Western Blot: Use 1–2 µg/mL for 60 min at RT.
Target Information
CD47 (Integrin-Associated Protein, IAP) is a ubiquitously expressed transmembrane glycoprotein that interacts with integrins and regulates their functions. Its engagement modulates signaling pathways such as heterotrimeric G protein activation and intracellular calcium increase upon cell adhesion.
CD47 acts as a receptor for the C-terminal domain of thrombospondin and plays roles in membrane transport and signal transduction. It is broadly distributed across tissues, reduced on Rh erythrocytes, and serves as a ligand for CD172a (SIRPα), inhibiting macrophage-mediated phagocytosis of CD47-positive cells.
Additionally, the CD47–CD172a system influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanotransduction, and neuronal development, particularly in synapse-rich brain and retinal regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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