Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody
Phospho-PLCG2 (Tyr1217) 폴리클로날 항체로, 인산화된 PLCG2의 Tyr1217 잔기를 특이적으로 인식합니다. Western blot 및 IHC(P)에서 검증되었으며, 인간, 생쥐, 랫트 시료에 반응합니다. PBS 기반 용액 형태로 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PLCG2 (Accession P16885), corresponding to amino acid residues around phosphorylated Tyr1217. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816107 |
Product Specific Information
This antibody detects endogenous levels of PLCG2 only when phosphorylated at Tyr1217.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate. Multiple mammalian PLC isozymes exist, including PLCβ1–4, PLCγ1–2, PLCδ1–2, and PLCε.
PLCδ1 acts as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It serves as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis.
PLCδ accumulation has been observed in Alzheimer’s disease brains, suggesting a pathological role. PLCδ2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, potentially serving as a marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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