Thermo Fisher Scientific IFN gamma Monoclonal Antibody (XMG1.2), Biotin, eBioscience

Thermo Fisher Scientific IFN gamma Monoclonal Antibody (XMG1.2), Biotin, eBioscience™

Applications and Tested Dilutions

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 561
• Alexa Fluor 660
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Brilliant UV 395
• Brilliant UV 615
• Brilliant UV 661
• Brilliant UV 737
• Brilliant UV 805
• Brilliant Violet 421
• Brilliant Violet 480
• Brilliant Violet 605
• Brilliant Violet 650
• Brilliant Violet 711
• Brilliant Violet 786
• eFluor 450
• eFluor 660
• FITC
• Functional Grade
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-Cyanine5.5
• Request custom conjugation

Product Specific Information

Description:
The XMG1.2 antibody reacts with mouse interferon (IFN) gamma and is a neutralizing antibody. Mouse IFN gamma is a 20 kDa factor produced by activated T, B, and NK cells, functioning as an antiviral and antiparasitic cytokine. In synergy with TNF alpha, IFN gamma inhibits proliferation of normal and transformed cells and exerts immunomodulatory effects on various cell types expressing high-affinity receptors for IFN gamma. Glycosylation does not affect its biological activity.

Applications Reported:
XMG1.2 has been reported for use in ELISA and Western blot (WB).

Applications Tested:
The antibody has been tested by ELISA and should be titrated for optimal assay performance.

Filtration:
0.2 µm post-manufacturing filtered.

Target Information

IFN gamma (Interferon gamma, Type II interferon):
A macrophage activation factor produced primarily by T-lymphocytes and NK cells in response to antigens and cytokines. It is a dimeric glycoprotein (~45 kDa) consisting of two 146 amino acid subunits. IFN gamma exhibits species-specific biological activity and functions include:

• Antiviral and tumor antiproliferative activity
• Induction of MHC class I and II
• Macrophage activation
• Enhanced immunoglobulin secretion by B lymphocytes

Human IFN gamma shows ~40% sequence homology with mouse IFN gamma. Mutations in the IFN gamma gene are associated with aplastic anemia.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.