Thermo Fisher Scientific Beta crystallin S Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Crystallins are divided into two main classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class forms the major structural proteins of the vertebrate eye lens, maintaining transparency and refractive index. Lens fiber cells lose their nuclei during development, so crystallins are synthesized once and retained throughout life, contributing to their remarkable stability.
Mammalian crystallins are categorized into alpha, beta, and gamma families, with beta and gamma forming a superfamily. Alpha and beta families are further divided into acidic and basic subgroups.
Crystallins have seven structural regions: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are monomeric, highly symmetrical proteins lacking connecting peptides and terminal extensions, and are differentially regulated after early development.
This gene encodes a protein initially classified as a beta-crystallin, but it is monomeric and shares greater sequence similarity with gamma-crystallins. It represents the predominant gamma-crystallin in adult lens tissue. Mutations or aging-related changes in gamma-crystallins are associated with cataract formation.

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