Thermo Fisher Scientific CD74 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Expected to recognize isoform a (NP_001020330.1) and isoform b (NP_004346.1).
• Tested in Peptide ELISA with antibody detection limit dilution of 1:128,000.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains 5 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the two extracellular domains
• Exon 4 encodes the transmembrane domain and cytoplasmic tail

DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains polymorphisms specifying peptide binding specificities, with hundreds of DRB1 alleles described. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

HLA-DR is expressed primarily on antigen-presenting cells such as:

• B lymphocytes
• Monocytes
• Macrophages
• Thymic epithelial cells
• Activated T lymphocytes

Three loci (DR, DQ, DP) encode the major expressed products of the human class II region.
These molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating the immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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