Thermo Fisher Scientific Phospho-SRC (Tyr530) Monoclonal Antibody (M261)
SRC 단백질의 Tyr530 인산화 상태를 검출하는 단일클론 항체로, 인간·생쥐·랫드에 반응합니다. Western blot에 적합하며, c-Src 및 관련 키나아제의 활성 조절 연구에 유용합니다. Protein A 정제, 0.5 mg/mL 농도, -20°C에서 보관합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M261 |
| Immunogen | Clone (M261) was generated from a phosphopeptide containing amino acids surrounding Tyr-530 at the C-terminus of human c-Src. This sequence has high homology to the conserved site in rat and mouse c-Src and is conserved in the c-Src family of kinases. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942617 |
Product Specific Information
This antibody detects a 60 kDa protein corresponding to c-Src on SDS-PAGE immunoblots of mouse SYF cells transformed with c-Src and treated with pervanadate. It also detects the conserved site in Lck (Tyr-505) in human Jurkat cells treated with pervanadate. This antibody may recognize several c-Src family members phosphorylated at the conserved Tyr-530 site.
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in embryonic development and cell growth regulation. It associates with various cell surface receptors to facilitate signal transduction and plays roles in cytoskeletal organization, cell cycle regulation, and apoptosis. The human SRC gene is located on chromosome 20. SRC activity is regulated by phosphorylation at Tyr416 (activation) and Tyr527 (inhibition). Mutations in SRC may contribute to malignant progression in colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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