Thermo Fisher Scientific ATF1 Polyclonal Antibody
ATF1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF 실험에 적합합니다. 고순도(>95%) 항원 친화 크로마토그래피 정제 제품이며, Human, Mouse, Rat에 반응합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 170–220 of Human ATF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803162 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
This gene encodes an activating transcription factor belonging to the ATF subfamily and bZIP (basic-region leucine zipper) family. It regulates downstream target genes related to growth, survival, and other cellular activities. The protein is phosphorylated at serine 63 by various kinases including PKA, CaMK I/II, MAPK, and CDK3, enhancing its transcriptional activity and promoting cell transformation. Chromosomal translocations involving this gene (with FUS on chromosome 16 or EWSR1 on chromosome 22) can generate chimeric proteins found in angiomatoid fibrous histiocytoma and clear cell sarcoma. A pseudogene exists on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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