Thermo Fisher Scientific ATG5 Polyclonal Antibody
ATG5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Affinity chromatography로 정제된 액상 제품이며, PBS/glycerol buffer에 보관. 세포자멸 및 오토파지 연구용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–275 of human ATG5 (NP_004840.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913599 |
Product Specific Information
Positive test controls include: HepG2, NIH/3T3, K-562, C6, SH-SY5Y.
Target localization: Cytoplasm, Peripheral membrane protein, Preautophagosomal structure membrane.
Immunogen sequence:
MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP LQWLSEHLSY PDNFLHISII PQPTD
Target Information
ATG5 (Autophagy Related 5) is an essential component of the autophagy machinery and plays a critical role in apoptosis. It is involved in mitochondrial quality control after oxidative stress, immune regulation, lymphocyte proliferation, MHC II antigen presentation, and adipocyte differentiation.
Upon conjugation with ATG12, the ATG5–ATG12 complex contributes to autophagosome formation and interacts with FADD to mediate autophagic cell death. This conjugate also modulates innate immune responses by interacting with RIG-I and VISA, thereby affecting type I interferon signaling.
Dysfunction of ATG5 has been linked to diseases such as spinocerebellar ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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