Thermo Fisher Scientific ETS1 Associated protein II Polyclonal Antibody
ETS1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등에 사용 가능. Human, Mouse, Rat에 반응하며, 친화 크로마토그래피로 정제됨. 액상 형태로 -20°C 보관, 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 330–360 on human Tyrosyl-DNA phosphodiesterase protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein and a member of the DNA-binding ETS protein family. It is a multifunctional protein with an N-terminal pointed domain, a central transactivation domain, and two autoinhibitory domains flanking the conserved C-terminal ETS domain. ETS1 interacts with PEBP2alphaA and p300/CBP, mediating transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase. It is activated by Ras/MAPK signaling and upregulated in resting T-cells. ETS1 activity is modulated by AP-1, Sp-1, c-myb, and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx, repressing MMP1 and BCL2 transactivation, and with STAT6 to modulate Socs-1 expression induced by IL-4. ETS1 also interacts with GATA3 to positively regulate Tax-1-dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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