Thermo Fisher Scientific CD31 (PECAM-1) Monoclonal Antibody (390), PE-Cyanine7, eBioscience
마우스 CD31(PECAM-1)을 인식하는 단클론 항체로, PE-Cyanine7 형광체가 결합된 제품입니다. Flow cytometry 및 동결 절편 면역조직화학에 적합하며, 0.5 µg/test로 사용 가능합니다. 광민감성이 있으므로 암조건에서 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD31 (PECAM-1) Monoclonal Antibody (390), PE-Cyanine7, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Flow Cytometry (Flow) | 0.5 µg/test | View 152 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Fish, Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine7 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 390 |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2734962 |
Available Formats
- Unconjugated
- APC
- Biotin
- Brilliant UV 661
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 711
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Red 755
- NovaFluor Yellow 610
- PE
- PE-Cyanine5
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The 390 monoclonal antibody reacts with mouse CD31 (PECAM-1, gpIIa), a 130–140 kDa surface protein expressed by endothelial cells and at low levels on leukocytes and platelets.
CD31 mediates homotypic interactions important for adhesion, cell-cell and cell-matrix interactions, and signal transduction.
- Applications Reported: Flow cytometric analysis.
- Applications Tested: Tested on mouse splenocytes at ≤ 0.5 µg/test (100 µL final volume).
- Light Sensitivity: Protect from light; tandem dye is photo-sensitive.
- Fixation: Samples can be stored up to 3 days at 4°C in the dark using IC Fixation Buffer or 1-step Fix/Lyse Solution.
- Excitation/Emission: 488–561 nm / 775 nm (Blue, Green, Yellow-Green Laser).
- Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD31 (PECAM-1) is an inhibitory coreceptor regulating T and B cell signaling via ITIM motifs. It is expressed throughout the vascular compartment, mainly at cell junctions.
Its N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions.
CD31 functions in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, and thrombosis, serving as a key vascular regulatory molecule.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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