Thermo Fisher Scientific PKN2 Polyclonal Antibody
PKN2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC(P), ICC/IF 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간에 반응하고 마우스·랫·소에 예측 반응성을 보입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 46–366 of PRK2 (Uniprot ID: Q16513) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.93 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155017 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2, Raji
- Predicted reactivity: Mouse (94%), Rat (94%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. It plays roles in cell cycle regulation, actin cytoskeleton assembly, cell migration, adhesion, tumor invasion, and transcriptional activation signaling.
It phosphorylates CTTN in hyaluronan-induced astrocytes, reducing its association with filamentous actin, and phosphorylates HDAC5, impairing its nuclear import.
PKN2 acts as a direct RhoA target, required for apical junction formation in epithelial cells, and is essential for G2/M phase progression and cytokinesis in an ECT2-dependent manner. It stimulates FYN kinase activity during keratinocyte differentiation and regulates epithelial bladder cell migration.
Additionally, PKN2 inhibits Akt pro-survival kinase activity and mediates Rho-induced transcriptional activation through the c-fos SRF pathway. It also phosphorylates HCV NS5B, stimulating HCV RNA replication.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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