Thermo Fisher Scientific KAT2B Polyclonal Antibody
PCAF 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunohistochemistry에 사용 가능. 마우스 시료 반응성. 동결건조 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 400–460 of mouse PCAF conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: PCAF.
Target Information
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It acetylates histones H3 and H4 as well as non-histone proteins such as ACLY, PLK4, and TBX5. PCAF inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. It also acts as a circadian transcriptional coactivator enhancing NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimer activity. PCAF is involved in heart and limb development by mediating TBX5 acetylation and regulating its nucleocytoplasmic shuttling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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