Thermo Fisher Scientific RGS22 Polyclonal Antibody
RGS22 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고순도 친화 크로마토그래피 정제 및 PBS/glycerol buffer에 보관됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RGS22 (Accession Q8NE09), corresponding to amino acid residues R551–K601 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853423 |
Product Specific Information
This antibody detects endogenous levels of total RGS22.
Target Information
Regulator of G-protein signaling (RGS) proteins contain a conserved 120 amino acid RGS domain that functions as a GTPase-activating protein, reducing signaling from receptor-activated G-alpha subunits.
RGS22 is a recently identified member of this family, localized to the testis, and interacts with GNA11, GNA12, and GNA13. It is implicated in spermiogenesis and is also expressed in several epithelial cancer cell lines, where it may influence metastasis. Overexpression of RGS22 reduces cell migration and invasiveness, suggesting its potential as a prognostic biomarker for metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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