Thermo Fisher Scientific ABCA4 Polyclonal Antibody
ABCA4 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 사람 및 생쥐 시료에 반응하며, 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABCA4 (Accession P78363), corresponding to amino acid residues M2151–R2201 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853427 |
Product Specific Information
This antibody detects endogenous levels of total ABCA4.
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans. It belongs to the ATP-binding cassette transporter sub-family A (ABC1), found exclusively in multicellular eukaryotes. The gene is mapped to chromosome 1p21–p13 and is expressed exclusively in retinal photoreceptor cells, mediating transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence microscopy and Western blot analyses have shown ABCR expression in foveal and peripheral cones as well as rod photoreceptors. Loss of central vision in patients with Stargardt macular dystrophy is associated with ABCR-mediated foveal cone degeneration.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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