Thermo Fisher Scientific VANGL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:20,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 1 and 266 of Human VANGL1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VANGL1,uniProtId:Q8TAA9-1,ncbiNodeId:9606,antigenRange:1-266,antigenLength:524,antigenImageFileName:PA5-29088_VANGL1_Q8TAA9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-29088_VANGL1_Q8TAA9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2546564

Product Specific Information

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.

Predicted reactivity: Mouse (91%), Rat (91%), Bovine (94%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.