Thermo Fisher Scientific NPR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: -

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Raji, K562
• Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (84%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Guanylyl cyclases catalyze the production of cGMP from GTP and are classified as soluble and membrane forms.
Membrane guanylyl cyclases (GC-A through GC-F) form a family of cell-surface receptors with similar topographic structures:

• Extracellular ligand-binding domain
• Single membrane-spanning domain
• Intracellular protein kinase-like and cyclase catalytic domains

GC-A and GC-B function as receptors for natriuretic peptides, also known as atrial natriuretic peptide receptor A and type B.
NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP).
Also see NPR3, which encodes a protein with ligand-binding transmembrane and short cytoplasmic domains.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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