Thermo Fisher Scientific beta Amyloid Polyclonal Antibody
Human, Mouse, Rat에 반응하는 beta Amyloid 폴리클로날 항체로 Western blot과 IHC에 사용 가능. 항원 친화 크로마토그래피로 정제된 1 mg/mL 액상 형태이며, PBS와 0.02% sodium azide 포함. Alzheimer’s 연구용으로 적합, 냉장 또는 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids of human amyloid A4 protein precursor (APP), corresponding to the amino terminus of the 4K Ab peptide generated by β- and γ-secretases |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152446 |
Product Specific Information
A suggested positive control is mouse brain tissue lysate.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide, 40–43 amino acids long, is generated from the beta-amyloid precursor protein (beta APP) in a two-step process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and 2, and nicastrin, which binds to the carboxyl-terminus of beta APP and modulates amyloid beta peptide production.
Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques, and neurofibrillary tangles.
Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy), and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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