Thermo Fisher Scientific DcR3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500
• Suggested positive control: Human heart tissue lysate
• Detects a band at ~33 kDa

Immunohistochemistry (IHC)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Detects DcR3 protein (~33 kDa) in Western blot applications.
• PA5-19924 can be used with blocking peptide PEP-0049.

Target Information

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by cytokines such as TNF and Fas ligand through their death domain-containing receptors (TNFR1 and Fas).
Cell death signals are transduced by DD-containing adapter molecules and members of the ICE/CED-3 protease family.
A novel DD-containing molecule, Daxx (death associated protein 6), binds specifically to the Fas death domain, enhances Fas-induced apoptosis, and activates the JNK pathway.
Daxx is widely expressed in fetal and adult human and mouse tissues, indicating its important role in Fas signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.