Thermo Fisher Scientific DcR3 Polyclonal Antibody
DcR3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 1 mg/mL 농도의 액상 형태입니다. 세포사멸 관련 연구용으로 사용되며, 냉장 또는 냉동 보관이 권장됩니다.
- 카탈로그번호
- PA519924
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
- Suggested positive control: Human heart tissue lysate
- Detects a band at ~33 kDa
Immunohistochemistry (IHC)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to amino acids near the amino terminus of human DcR3 precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Refrigerate at 2–8°C up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152750 |
Product Specific Information
- Detects DcR3 protein (~33 kDa) in Western blot applications.
- PA5-19924 can be used with blocking peptide PEP-0049.
Target Information
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by cytokines such as TNF and Fas ligand through their death domain-containing receptors (TNFR1 and Fas).
Cell death signals are transduced by DD-containing adapter molecules and members of the ICE/CED-3 protease family.
A novel DD-containing molecule, Daxx (death associated protein 6), binds specifically to the Fas death domain, enhances Fas-induced apoptosis, and activates the JNK pathway.
Daxx is widely expressed in fetal and adult human and mouse tissues, indicating its important role in Fas signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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