Thermo Fisher Scientific Phospho-p38 MAPK (Thr180, Tyr182) Recombinant Rabbit Monoclonal Antibody (4D0A9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence: MTGYV

Target Information

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in their tissue expression and affinity for upstream activators and downstream effectors. Upon exposure to stimuli such as tumor necrosis factor, interleukin-1, or heat shock, MAPK kinase-3 becomes activated by phosphorylation. Activated MAPK kinase-3/6 phosphorylates Thr180 and Tyr182 residues in p38 MAPK. Phospho-p38 MAPK then activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.