Thermo Fisher Scientific CRP Monoclonal Antibody (C7), Biotin

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

This antibody detects the antigen both in the presence and in the absence (samples containing EDTA) of Ca²⁺.

Target Information

C-reactive protein (CRP) is a major cyclic, pentameric acute-phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit consists of 206 amino acids and has a molecular weight of approximately 24 kDa.
CRP is synthesized by the liver, and its plasma concentration increases markedly during inflammatory processes. It initiates the classical complement cascade, binds to nuclear components such as chromatin and histones, and plays a crucial role in innate immunity.

CRP levels can increase 100–1000 fold in response to injury, infection, or inflammation. It acts as an opsonin, activates monocytes/macrophages, and may serve as a scavenger during cell necrosis. Elevated basal CRP levels are associated with increased risk of hypertension and cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.