Thermo Fisher Scientific Importin 11 Polyclonal Antibody
Importin 11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로 Western Blot에 적합. 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 4°C 또는 -20°C 보관 권장.
- 카탈로그번호
- PA141600
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 1–50 of human Importin-11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2127664 |
Product Specific Information
- Suggested positive control: HeLa lysate, antigen standard for IPO11 (transient overexpression lysate).
Target Information
IPO11 functions in nuclear protein import as a nuclear transport receptor. It serves as a receptor for nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through nucleoporin binding. The complex is translocated through the pore by an energy-dependent, Ran-mediated mechanism. On the nucleoplasmic side, Ran binding causes dissociation of the complex, and importin is re-exported to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is governed by the asymmetric distribution of Ran-GTP and Ran-GDP forms between nucleus and cytoplasm. IPO11 mediates nuclear import of UBE2E3 and RPL12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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