Thermo Fisher Scientific TBC1D22A Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TBC1D22A. Recombinant protein control fragment (Product #RP-91366). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TBC1D22A,uniProtId:Q8WUA7-1,ncbiNodeId:9606,antigenRange:313-445,antigenLength:517,antigenImageFileName:PA5-51526_TBC1D22A_Q8WUA7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51526_TBC1D22A_Q8WUA7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648260

Product Specific Information

Immunogen sequence: HPASGYVQGI NDLVTPFFVV FICEYIEAEE VDTVDVSGVP AEVLCNIEAD TYWCMSKLLD GIQDNYTFAQ PGIQMKVKML EELVSRIDEQ VHRHLDQHEV RYLQFAFRWM NNLLMREVPL RCTIRLWDTY QSE

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 59%.

Target Information

TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid protein that contains one Rab-GAP TBC domain and is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms of TBC1D22A exist due to alternative splicing events. The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.