Thermo Fisher Scientific TBC1D22A Polyclonal Antibody
Human TBC1D22A 단백질을 인식하는 Rabbit Polyclonal 항체. IHC 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며, 연구용으로만 사용 가능.
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- PA551526
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TBC1D22A. Recombinant protein control fragment (Product #RP-91366). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648260 |
Product Specific Information
Immunogen sequence:
HPASGYVQGI NDLVTPFFVV FICEYIEAEE VDTVDVSGVP AEVLCNIEAD TYWCMSKLLD GIQDNYTFAQ PGIQMKVKML EELVSRIDEQ VHRHLDQHEV RYLQFAFRWM NNLLMREVPL RCTIRLWDTY QSE
Sequence identity:
- Mouse: 92%
- Rat: 59%
Target Information
TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid protein containing one Rab-GAP TBC domain and functions as a GTPase-activating protein for Rab family members. Multiple isoforms exist due to alternative splicing.
The gene is located on human chromosome 22, which contains over 500 genes and is the second smallest human chromosome. Mutations in genes on chromosome 22 are associated with Phelan-McDermid syndrome, neurofibromatosis type 2, autism, and schizophrenia.
Translocations between chromosomes 9 and 22 can result in the Philadelphia chromosome, producing the BCR-Abl fusion protein, a potent activator of cell proliferation implicated in various leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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