Thermo Fisher Scientific BMP-3 Polyclonal Antibody
인간 BMP-3 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 보존제가 포함되지 않은 동결건조 형태입니다. 교차 반응성이 낮고, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human BMP-3 (Gln363–Arg472) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609466 |
Product Specific Information
- In direct ELISAs, less than 1% cross-reactivity with recombinant human BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7 is observed.
- This antibody very weakly recognizes native dimeric BMP-3.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody (LAL method).
Target Information
BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily. They stimulate bone matrix protein production and regulate stromal cell and osteoclast proliferation, which are key steps in bone marrow development.
In addition to promoting ectopic bone and cartilage formation, BMPs influence the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal, epithelial, hematopoietic, and neuronal cells.
BMP3 is highly expressed in lung, ovary, and small intestine, and participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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