Thermo Fisher Scientific CD8A (Cytotoxic-andSuppressor T-Cell Marker) Monoclonal Antibody (C8/468)
CD8A 단백질을 표적하는 Monoclonal Antibody로, Cytotoxic 및 Suppressor T 세포 마커 검출에 적합합니다. IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능하며, Human 시료에 반응합니다. 고순도 Protein A/G 정제, -20°C 보관.
- 카탈로그번호
- 925-MSM1-P1ABX
- 판매단위
- pk
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Thermo Fisher Scientific CD8A (Cytotoxic and Suppressor T-Cell Marker) Monoclonal Antibody (C8/468)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C8/468 |
| Immunogen | Human CD8 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
- CF 488 conjugate available
- Custom conjugation upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family, essential in T-cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β), functioning as a co-receptor with the TCR for MHC-I molecules. CD8α binds directly to MHC-I and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes recruits Lck kinase, promoting cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are critical for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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